X
Pharma Advancement
  • Home
  • Drug Development
    • All
    • Clinical Trials
    • FDA Approvals
    • Research & Development
    development of new antibiotics

    EMA guidance supports development of new antibiotics

    Thermo Fisher Scientific Announces Collaboration with Northeastern University to Advance Biopharmaceutical Characterization and Monitoring Workflows

    Commercial Success In New Biopharmaceutical Innovation Era

    Proteros and AstraZeneca Boost Collaboration Agreement

    Conver to wp

    AbbVie and Cugene Join Forces Concerning Autoimmune Disorders and Cancer

    Drug Imagent For Therapeutic Platform

    Japan Pharma Lobby Says-Price Scheme Is Causing Drug Lag

    Charles River and Valence Discovery Announce Strategic Partnership to Provide Clients with AI-Enabled Drug Design Capabilities

    Charles River and Valo Launch Logica, an Integrated AI-Powered Drug Discovery Solution to Rapidly Deliver Optimized Preclinical Assets

    AstraZeneca announces phase IV ASCENT trial of Tudorza Pressair in patients with COPD meets primary efficacy endpoint

    AstraZeneca announces plans for new strategic R&D centre and Alexion headquarters in Cambridge, Massachusetts

    Lynparza approved in the EU for BRCA-mutated metastatic pancreatic cancer

    Major Success Factors For Clinical Development Organizations

    ArisGlobal Expands LifeSphere Clinical Portfolio with Landmark Customer Wins in APAC & Middle East

    ArisGlobal Expands LifeSphere Clinical Portfolio with Landmark Customer Wins in APAC & Middle East

  • Manufacturing
  • Supply Chain
  • Facilities
  • Health & Nutrition
  • Events
  • Contact Us
No Result
View All Result
  • Home
  • Drug Development
    • All
    • Clinical Trials
    • FDA Approvals
    • Research & Development
    development of new antibiotics

    EMA guidance supports development of new antibiotics

    Thermo Fisher Scientific Announces Collaboration with Northeastern University to Advance Biopharmaceutical Characterization and Monitoring Workflows

    Commercial Success In New Biopharmaceutical Innovation Era

    Proteros and AstraZeneca Boost Collaboration Agreement

    Conver to wp

    AbbVie and Cugene Join Forces Concerning Autoimmune Disorders and Cancer

    Drug Imagent For Therapeutic Platform

    Japan Pharma Lobby Says-Price Scheme Is Causing Drug Lag

    Charles River and Valence Discovery Announce Strategic Partnership to Provide Clients with AI-Enabled Drug Design Capabilities

    Charles River and Valo Launch Logica, an Integrated AI-Powered Drug Discovery Solution to Rapidly Deliver Optimized Preclinical Assets

    AstraZeneca announces phase IV ASCENT trial of Tudorza Pressair in patients with COPD meets primary efficacy endpoint

    AstraZeneca announces plans for new strategic R&D centre and Alexion headquarters in Cambridge, Massachusetts

    Lynparza approved in the EU for BRCA-mutated metastatic pancreatic cancer

    Major Success Factors For Clinical Development Organizations

    ArisGlobal Expands LifeSphere Clinical Portfolio with Landmark Customer Wins in APAC & Middle East

    ArisGlobal Expands LifeSphere Clinical Portfolio with Landmark Customer Wins in APAC & Middle East

  • Manufacturing
  • Supply Chain
  • Facilities
  • Health & Nutrition
  • Events
  • Contact Us
No Result
View All Result
Pharma Advancement
No Result
View All Result
Home Facilities & Operation

Introducing the CosmoDry System: Innovative Horizontal Paddle Vacuum Dryer

Yuvraj_pawp by Yuvraj_pawp
25th July 2014
in Facilities & Operation

Maximum ease of cleaning, maintenance and internal inspection: a mix of qualities that make CosmoDry System® the ideal solution even for multi-product applications.

CosmoDry System® is the innovative horizontal paddle vacuum dryer created by Italvacuum as the result of a deep analysis, conducted in cooperation with the most demanding customers, regarding the most urgent requirements of their production.

Power, loading flexibility, drying speed, ease of unloading, maximum product quality. These are all fundamental values. But Italvacuum went further, in order to facilitate cleaning and internal inspection. A quality that allows to maintain over time the machine’s perfect efficiency and to optimize the production processes.

CosmoDry System® is based on an operating philosophy conceived for the drying of wet powders coming from filtration or centrifugation stages and it is suitable for the production of Active Pharmaceutical Ingredients (API), Fine Chemical and Intermediates.

CosmoDry System® consists of a horizontal cylindrical chamber, equipped with a concentric agitator, fitted with an heated shaft dismountable in sections: this is the great added value of the CosmoDry System®, setting it apart from conventional paddle vacuum dryers.

The peculiar configuration of the agitator enables continuous stirring of the product and facilitates its thermal exchange, reducing drying time. Moreover, it was designed to limit mechanical and thermal stresses, thus allowing the treatment of thermo-sensitive products. But that is not all. Its special features allow to reduce product deposition at a minimum, providing an easy and efficient unloading operation, for which a dedicated operative cycle has been introduced.

Finally a value that has always been a milestone for Italvacuum: safety. CosmoDry System® is safe for the product and the operators, because it is designed and manufactured in compliance with the increasingly strict safety standards and according to cGMP and ATEX regulations.

Constructive details

For the parts that are in contact with the product CosmoDry System® is built in AISI 316L stainless steel, but other weldable materials are also available if requested by customer, for instance ALLOY C-22 and AISI 904L.

The walls of the drying chamber, the port lid and the agitator shaft are heated through diathermic liquid circulation. Internal surfaces are mirror polished or electropolished in order to optimize resistance to corrosion, reduce friction on the product and simplify cleaning operations.

The agitator shaft is equipped with a double mechanical seal system, conceived to guarantee perfect vacuum tightness and absolute purity of the dried batch, avoiding any risk of product contamination. The mechanical seal can be pressurized through liquid or inert gas.

Maximum ease of cleaning and inspection

Easy internal cleaning is guaranteed by an efficient C.I.P. system, that allows the washing of all the parts in contact with the product.

The frontal port lid and the easy disassembling of the agitator in different parts provide great accessibility for inspection and SWAB testing: no bulky equipment is required, thus preventing long machine stops. A feature that makes CosmoDry System® unique compared to vacuum dryers.

The exterior of CosmoDry System® is easy to clean as well. The watertight external cladding of the entire machine (cGMP “particle free” configuration) covers the insulation, the electric wiring and the hydraulic and pneumatic piping. In addition no support frame occupies the sterile room, only the drying chamber flanged to the wall. This makes external cleaning extremely easy, preventing product accumulation. These features, together with the partitioning solution, allow clean room installation, guaranteeing pressurization and separation of sterile room from technical room.

Turnkey systems

Italvacuum is the only manufacturer in the world that, in addition to the dryer itself, can design and build internally all the auxiliary units that complete the plant, properly sizing them to meet every process requirement, vacuum system included:

  1. High vacuum group SAURUS 939
  2. Vacuum condensation group for reduction of drying time and recovery of extracted solvents
  3. External safety filtering unit for powders containment
  4. Heating and cooling group for system thermoregulation
  5. Control panels with PLC for complete plant management, provided with software that is certifiable according to CFR 21 – Part 11 regulations, and that guarantees reproducibility of the dried batches and communication with centralized supervision systems

Dimensions

CosmoDry System® presents a great loading flexibility. It is manufactured in volumes ranging from 150l to 4,400l. The loading capacity can vary from 30% to 80% of the chamber’s volume, according to the processed product, meeting in this way the multiple needs of chemical and pharmaceutical industries.

Previous Post

Mezzion Pharma Initiates Clinical Development Program To Evaluate Udenafil In Adolescents With Single Ventricle Heart Defects

Next Post

Sterilising Difficult Items with a Small Vacuum Autoclave

Related Posts

New Concept Allows Physical Partnering Event
Facilities & Operation

New Concept Allows Physical Partnering Event

11th September 2020
Pfizer and Flatiron Health Announce Expanded Strategic Collaboration to Unlock Power of Real-World Evidence in Oncology
Facilities & Operation

Pfizer and Flatiron Health Announce Expanded Strategic Collaboration to Unlock Power of Real-World Evidence in Oncology

27th September 2019
Catalent To Open New Clinical Supply Facility In San Diego
Drug Development

Catalent To Open New Clinical Supply Facility In San Diego

17th September 2019
IQVIA MedTech
Facilities & Operation

IQVIA Launches IQVIA MedTech Dedicated to Medical Device and Diagnostics Industry

14th May 2019
Catalent Invests $14 Million At Its Eberbach, Germany Softgel Facility
Facilities & Operation

Catalent Invests $14 Million At Its Eberbach, Germany Softgel Facility

24th April 2019
Blackstone Life Sciences and Novartis Launch Anthos Therapeutics to Develop Innovative Medicines for Cardiovascular Disease
Facilities & Operation

Blackstone Life Sciences and Novartis Launch Anthos Therapeutics to Develop Innovative Medicines for Cardiovascular Disease

1st March 2019
Next Post

Sterilising Difficult Items with a Small Vacuum Autoclave

Latest News

Global Biopharmaceutical Bioseparation Market Eyeing $20bn
Manufacturing

Global Biopharmaceutical Bioseparation Market Eyeing $20bn

4th July 2022
FDA Advises Adding Omicron BA.4, 5 To COVID-19 Boosters
Manufacturing

FDA Advises Adding Omicron BA.4, 5 To COVID-19 Boosters

4th July 2022
COVID-19 Omicron-Specific Vaccines Could Be Used As Boosters
Manufacturing

COVID-19 Omicron-Specific Vaccines Could Be Used As Boosters

4th July 2022
Fasenra shows consistent safety and sustained efficacy in long-term Phase III BORA trial in severe eosinophilic asthma
Manufacturing

AstraZeneca Cites Early Lung Cancer Immunotherapy Success

4th July 2022
FDA Experts Recommend Changing COVID Jab Formulation In Fall
Manufacturing

FDA Experts Recommend Changing COVID Jab Formulation In Fall

30th June 2022
Pharma Advancement

About Us

Pharma Advancement is a leading Pharma information centric website. On one side Pharmaadvancement.com has established itself as one of the most efficient and comprehensive source of Pharma information online, dedicated to providing decision makers in all the Pharma industry sectors with reliable, accurate and useful insights into happenings in the Pharma sector.

Qucik Links

  • Drug Development
  • Manufacturing
  • News
  • Events & Conferences
  • Newsletter Archive

Resources

  • Advertise with us
  • Contact Us
  • Download Mediapack

System

  • Search
  • Sitemap
  • RSS Feed

© 2017 Copyright © Valuemediaservices 2017 All rights reserved.

No Result
View All Result
  • Home
  • Drug Development
  • Manufacturing
  • Supply Chain
  • Facilities
  • Health & Nutrition
  • Events
  • Contact Us

© 2017 Copyright © Valuemediaservices 2017 All rights reserved.

Login to your account below

Forgotten Password?

Fill the forms bellow to register

All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In