Bluesight has introduced a fully redesigned 340BCheck platform, describing it as a compliance command center created to support covered entities in maintaining compliance standards and protecting their 340B programs. The updated software expands upon technology initially developed by Sectyr and later acquired by Bluesight in 2024. Following the acquisition, the company broadened the platform’s functionality, including the addition of a 100% transaction audit in 2025, before unveiling the newly redesigned interface. The redesigned 340BCheck platform incorporates Bluesight’s workflow-driven design together with core compliance infrastructure.
The platform includes a wide range of current and planned capabilities, such as full transaction auditing across patient, provider, and location definitions, OPAIS database synchronization, contract pharmacy and pharmacy service agreement management, Medicare cost report maintenance, Medicaid exclusion file validation, policy and procedure management, mock HRSA audits, as well as integrated documentation and task management.
The launch arrives during what the company described as a difficult period for the 340B program, which has become increasingly important to the financial stability of healthcare organizations. During fiscal year 2025, HRSA audited 115 covered entities, with nearly half receiving adverse findings. Incorrect OPAIS records were identified in 75% of those audited entities, reinforcing the need for broader compliance infrastructure beyond transaction-level auditing alone. At the same time, healthcare organizations are managing evolving manufacturer data-sharing demands, ongoing discussions around rebate-based distribution models from HRSA, and changing contract pharmacy disputes occurring at the state level.
As compliance expectations continue to grow, covered entities are facing significantly greater regulatory and documentation burdens while often relying on the same operational teams they had several years ago. Many organizations are also simultaneously expanding their 340B programs, contributing to a rising number of auditable transactions.
Bluesight said the redesigned 340BCheck platform was built specifically to help covered entities remain continuously prepared for HRSA audits. According to the company, the workflows were structured around actual HRSA audit requirements, beginning with the standards necessary for a successful audit and then moving on to provide workflows designed to support continuous audit readiness.
The updated system builds on years of operational experience among 340B program teams while introducing a faster and more intuitive interface.
“340B compliance used to be about spot checks, but today it’s about continuous readiness,” noted Kevin MacDonald. “Audit scrutiny is rising, manufacturer requirements are expanding, and a potential rebate model could add entirely new documentation layers — without any increase in team size for most organizations. Covered entities should be audit-ready every single day, not just when HRSA shows up.”
The redesigned 340BCheck platform was previewed at both ASHP Midyear in December 2025 and the 340B Coalition Annual Conference in February 2026, where program managers responded positively to its emphasis on continuous compliance coverage. Bluesight also stated that it is developing additional capabilities designed for a rebate-based pricing model inside the 340B program, including tools supporting procurement decisions, aligning 340B transaction audits with rebate-eligible transactions, and rebate payment tracking.
Bluesight uses intelligence to power hospital operations, making procurement, compliance, and inventory management simpler . Bluesight guarantees that health systems safeguard every patient and maximise every dollar with its array of industry-leading technologies. Every day, more than 3,000 hospitals in the US and Canada depend on Bluesight for effective and secure operations.
