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Strong Protection By New Sanofi Vaccine Against Severe COVID

Content Team by Content Team
28th February 2022
in News
Strong Protection By New Sanofi Vaccine Against Severe COVID

In the fight against COVID-19, the world may soon have another vaccine choice. A positive result from late-stage clinical testing of a novel vaccine that will be called Vidprevtyn has been announced by Sanofi and GSK by the formers representative. Both companies want to seek approval for the shots in the United States and Europe.

Vidprevtyn happens to be a protein subunit vaccine, which means it teaches the immune system how to recognise and fight the SARS-CoV-2 virus using harmless protein fragments. It’s a more traditional vaccine than mRNA as well as adenovirus vector vaccines, which deliver the genetic instructions for building the spike protein into cells, where they can be created and displayed like mug shots for the immune system to locate and battle against.

These vaccines may be stored at refrigerator settings, making them more convenient to use in regions where ultracold storage is unavailable. Because they use more familiar technology, there’s a chance that people who have rejected other COVID-19 vaccines will find these vaccines more appealing.

Study Findings Look Promising

The vaccination is administered in two doses, three weeks apart. More than 10,000 people were enrolled in phase 3 trials to evaluate the vaccine in the United States, Africa, Asia, and Latin America. A third dosage of the vaccine is being tested as a booster in separate research.

After two doses were administered to people who had no antibodies against the SARS-CoV-2 virus, the vaccine was found to be

  • 58 percent successful in reducing the symptoms of Covid-19
  • 75% efficient in preventing moderate-to-severe cases.
  • 100% effective against acute COVID-19 disease, which included hospitalizations.

The novel vaccination had lower protection against symptomatic disease than Pfizer and Moderna’s mRNA vaccines, but it was also evaluated under different circumstances, including when the new variations were circulating.

Sanofi executive vice president Thomas Triomphe remarked that they are quite delighted with these statistics. As per him, no other worldwide Phase 3 efficacy study with so many variations of concern, including Omicron, has been done during this period, and these efficacy data are close to current clinical data from licenced vaccines.

When administered to people who had previously received Pfizer, Moderna, or adenovirus-vector vaccinations like the Johnson & Johnson or AstraZeneca shots, the vaccine increased neutralising antibodies by 18 to 30-fold, and according to the companies, the trials revealed no safety concerns.

More Than Million Doses Already Dispensed

The vaccine was produced with $2.1 billion from Operation Warp Speed, a groundbreaking initiative to bring effective COVID-19 vaccinations to the United States and the rest of the world. The company claims to have manufactured and distributed 100 million doses, with ambitions to generate up to 400 million more.

According to a business spokesperson, the vaccine will most likely be used as a booster in the US and European markets, where several people have undergone their initial immunisation series. Vidprevtyn’s development was put on hold because an initial formulation failed to evoke a strong immunological response in elderly people. The manufacturers modified their products and retested them. According to a Sanofi official, the current results are from a phase 3 trial that began in May 2021 and reflect actual tests of the shots against numerous strains, especially Delta and Omicron.

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