X
Pharma Advancement
  • Home
  • Drug Development
    • All
    • Clinical Trials
    • FDA Approvals
    • Research & Development

    Nasal Spray Shows Its Effect Against New COVID Variants

    Mid-Point Regulatory Science Strategy Study Published By EMA

    AADC Inadequacy To Be Handled By A Novel Gene Therapy

    New Drug Explored For Epilepsy Gets $3M Funding In Australia

    Care Access Research Launches Alliance to Provide Infrastructure for COVID-19 Trials

    Faster Clinical Trial Nods Planned By The UK To Curb Issues

    Pharma Drugs Gain From Tardigrade Proteins, Says Research

    Pharma Drugs Gain From Tardigrade Proteins, Says Research

    U.S. FDA Approves DARZALEX Split-Dosing Regimen

    EMA Keeping A Close Watch On Critical Medicine Shortages

    Pathways Laid Down By The CMS For Drug Price Negotiations

    Pathways Laid Down By The CMS For Drug Price Negotiations

    Efficacy Shown On Cystic Fibrosis Patients In 4-Year Study

  • Manufacturing
  • Supply Chain
  • Facilities
  • Health & Nutrition
  • Events
  • Contact Us
No Result
View All Result
  • Home
  • Drug Development
    • All
    • Clinical Trials
    • FDA Approvals
    • Research & Development

    Nasal Spray Shows Its Effect Against New COVID Variants

    Mid-Point Regulatory Science Strategy Study Published By EMA

    AADC Inadequacy To Be Handled By A Novel Gene Therapy

    New Drug Explored For Epilepsy Gets $3M Funding In Australia

    Care Access Research Launches Alliance to Provide Infrastructure for COVID-19 Trials

    Faster Clinical Trial Nods Planned By The UK To Curb Issues

    Pharma Drugs Gain From Tardigrade Proteins, Says Research

    Pharma Drugs Gain From Tardigrade Proteins, Says Research

    U.S. FDA Approves DARZALEX Split-Dosing Regimen

    EMA Keeping A Close Watch On Critical Medicine Shortages

    Pathways Laid Down By The CMS For Drug Price Negotiations

    Pathways Laid Down By The CMS For Drug Price Negotiations

    Efficacy Shown On Cystic Fibrosis Patients In 4-Year Study

  • Manufacturing
  • Supply Chain
  • Facilities
  • Health & Nutrition
  • Events
  • Contact Us
No Result
View All Result
Pharma Advancement
No Result
View All Result
Home Drug Development Clinical Trials

Nippon Chemiphar announces positive results from phase-1 trial of NC-2500, a novel XOR inhibitor

Yuvraj_pawp by Yuvraj_pawp
30th November 2017
in Clinical Trials

Nippon Chemiphar has announced that the phase-1 clinical trial of NC-2500, a novel xanthine oxidoreductase (XOR) inhibitor, was completed, indicating that it has potential to reduce the risk of gout flare, one of major issues of current treatments for hyperuricemia/gout. The randomized, single-blind, placebo-controlled, dose-escalation study was conducted to evaluate safety, pharmacological characteristics and pharmacokinetics of NC-2500 in healthy volunteers with single and multiple dosing, once daily for 7 days.

NC-2500 showed favorable urate-lowering properties which may make a difference in gout treatment. NC-2500 lowered serum urate levels gradually to the same extent as current XOR inhibitors through 7 days, which could decrease the risk of acute flare in gout. Acute flare due to rapid urate reduction is one of the major issues in the initial phase of current therapy, which impairs patients’ quality of life and adherence, frequently resulting in failing sufficient control of serum urate and then worsening the disease. NC-2500 is expected to have potential to resolve these issues by its unique urate-lowering property to avoid acute flare, with no or minimal titration. As for safety, NC-2500 was well-tolerated and adverse events were infrequent, transient, mild, and comparable to placebo. Furthermore, NC-2500 was hardly excreted through the kidneys, which can be a favorite profile for patients with renal impairment, frequently observed in gout.

Nippon Chemiphar also completed pre-clinical studies on NC-2700, a novel urate transporter 1 (URAT1) inhibitor, enhancing excretion urate to urine. NC-2700 showed not just a potent uricosuric effect, but also pH-raising of the urine with lowered pH in an animal model, which could decrease the risk of renal calculus and nephrotoxicity with urate crystals in the urine, the most common issue with uricosuric therapy. NC-2700 is now ready for a phase-1 clinical study.

Focusing on research in hyperuricemia/gout, Nippon Chemiphar has been developing NC-2500 and NC-2700, attractive product candidates which may resolve current issues in treating gout and offer new treatment options to patients for their better outcomes and quality of life. To accelerate development and make them available for patients earlier, Nippon Chemiphar is considering collaboration or partnering for further development and welcomes proposals.

Previous Post

Kyowa Hakko Kirin Submits the Partial Change Approval Application of Mogamulizumab in Japan

Next Post

Merck, Pfizer announce phase III JAVELIN Gastric 300 trial in patients with pre-treated advanced gastric cancer fails to meet primary endpoint

Related Posts

Care Access Research Launches Alliance to Provide Infrastructure for COVID-19 Trials
Clinical Trials

Faster Clinical Trial Nods Planned By The UK To Curb Issues

22nd March 2023
Clinical Trials

Efficacy Shown On Cystic Fibrosis Patients In 4-Year Study

18th March 2023
Clinical Trials

Monash University In Australia Leads $15M Mitochondrial Clinical Trial Drive

18th March 2023
Clinical Trials

Default Eligibility Results In Better Clinical Trial Nods

10th March 2023
Clinical Trials

Temperature Stable TB Vaccine Gives Out Immune Response

10th March 2023
Clinical Trials

More Monitoring Required of Institutional Review Boards

24th February 2023
Next Post

Merck, Pfizer announce phase III JAVELIN Gastric 300 trial in patients with pre-treated advanced gastric cancer fails to meet primary endpoint

Latest News

Cathay Cargo signs global airline partnership with Tower Cold Chain
Packaging & Logistic

Cathay Cargo signs global airline partnership with Tower Cold Chain

31st March 2023
Quotient Sciences completes integration of drug substance into Translational Pharmaceutics Platform
Facilities & Operation

£277m Funding Set To Benefit UK Life Sciences Manufacturing

31st March 2023
Drug Development

Nasal Spray Shows Its Effect Against New COVID Variants

27th March 2023
FDA Approvals

Mid-Point Regulatory Science Strategy Study Published By EMA

27th March 2023
Drug Development

AADC Inadequacy To Be Handled By A Novel Gene Therapy

24th March 2023
Pharma Advancement

About Us

Pharma Advancement is a leading Pharma information centric website. On one side Pharmaadvancement.com has established itself as one of the most efficient and comprehensive source of Pharma information online, dedicated to providing decision makers in all the Pharma industry sectors with reliable, accurate and useful insights into happenings in the Pharma sector.

Qucik Links

  • Drug Development
  • Manufacturing
  • News
  • Events & Conferences
  • Newsletter Archive

Resources

  • Advertise with us
  • Contact Us
  • Download Mediapack

System

  • Search
  • Sitemap
  • RSS Feed

© 2017 Copyright © Valuemediaservices 2017 All rights reserved.

No Result
View All Result
  • Home
  • Drug Development
  • Manufacturing
  • Supply Chain
  • Facilities
  • Health & Nutrition
  • Events
  • Contact Us

© 2017 Copyright © Valuemediaservices 2017 All rights reserved.

Login to your account below

Forgotten Password?

Fill the forms bellow to register

All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In