X
Saturday, July 12, 2025
Pharma Advancement
  • Home
  • Articles
  • Drug Development
    • All
    • Clinical Trials
    • FDA Approvals
    • Research & Development
    Avadel Pharmaceuticals Receives

    Avadel Pharmaceuticals Receives Orphan Drug Designation from FDA for LUMRYZ™ (sodium oxybate) for Extended-Release Oral Suspension for the Treatment of Idiopathic Hypersomnia

    Robots and AI in Drug

    Robots and AI in Drug Discovery Are Transforming Medicine

    Stringent Policy around COVID Vaccines Laid by FDA

    Stringent Policy around COVID Vaccines Laid by FDA

    Pharmaceutical-Chemicals Market Booms with Rising API Demand

    Pharmaceutical Chemicals Market Booms with Rising API Demand

    Next in Pharma 2025 Innovations

    Next in Pharma 2025: Innovations Shaping the Future

    Work Smart: Go for Hands-Free Lab Informatics at the Bench, Not Scribbled Notes and Delayed Documentation at Your Desk

    Clinical Development

    AI Revolutionizing Drug Discovery and Clinical Development

    Drug-Development

    China’s Super Me-Too Drug Development: A New Pharma Frontier

    Omics Based Clinical Trials

    Asia Pacific Omics-Based Clinical Trials Market Growth

  • Manufacturing
  • Supply Chain
  • Facilities
  • Insights
  • Events
  • Contact Us
No Result
View All Result
  • Home
  • Articles
  • Drug Development
    • All
    • Clinical Trials
    • FDA Approvals
    • Research & Development
    Avadel Pharmaceuticals Receives

    Avadel Pharmaceuticals Receives Orphan Drug Designation from FDA for LUMRYZ™ (sodium oxybate) for Extended-Release Oral Suspension for the Treatment of Idiopathic Hypersomnia

    Robots and AI in Drug

    Robots and AI in Drug Discovery Are Transforming Medicine

    Stringent Policy around COVID Vaccines Laid by FDA

    Stringent Policy around COVID Vaccines Laid by FDA

    Pharmaceutical-Chemicals Market Booms with Rising API Demand

    Pharmaceutical Chemicals Market Booms with Rising API Demand

    Next in Pharma 2025 Innovations

    Next in Pharma 2025: Innovations Shaping the Future

    Work Smart: Go for Hands-Free Lab Informatics at the Bench, Not Scribbled Notes and Delayed Documentation at Your Desk

    Clinical Development

    AI Revolutionizing Drug Discovery and Clinical Development

    Drug-Development

    China’s Super Me-Too Drug Development: A New Pharma Frontier

    Omics Based Clinical Trials

    Asia Pacific Omics-Based Clinical Trials Market Growth

  • Manufacturing
  • Supply Chain
  • Facilities
  • Insights
  • Events
  • Contact Us
No Result
View All Result
Pharma Advancement
No Result
View All Result
Home Americas

Eisai presents data on its anti-fractalkine monoclonal antibody E6011

Yuvraj_pawp by Yuvraj_pawp
13th June 2016
in Americas, News

Note* - All images used are for editorial and illustrative purposes only and may not originate from the original news provider or associated company.

Eisai Co Ltd. announced that interim analyses on the latest data for the world’s first anti-fractalkine monoclonal antibody E6011, discovered by Eisai’s research subsidiary KAN Research Institute Inc. from two respective Phase I/II clinical studies in Crohn’s disease and rheumatoid arthritis (Study 101 and Study 103) showed positive results for safety and tolerability, and exploratory assessment suggested clinical activity for E6011. These data have been presented at a number of recent academic conferences.

 

Study 101 is a multicenter, open-label study to evaluate mainly the safety and tolerability of E6011 in 21 Japanese patients with Crohn’s disease who respond inadequately to conventional therapy which includes anti-tumor necrosis factor (TNF) therapies. The results of Study 101 were presented at Digestive Disease Week 20161 in May.

 

Study 103 is a multicenter, open-label study to evaluate mainly the safety and tolerability of E6011 in 27 Japanese patients with rheumatoid arthritis who respond inadequately to methotrexate or anti-TNF therapy. The results of study 103 were presented at the American College of Rheumatology (ACR) Annual Meeting2 in November 2015, the Annual General Assembly and Scientific Meeting of the Japan College of Rheumatology3 in April 2016 and the Annual European Congress of Rheumatology EULAR 20164in June. Additionally, the presentation on the results of Study 103 was accepted as a late-breaking abstract for the ACR Annual Meeting 2015.

 

Fractalkine is expressed on the surface of vascular endothelial cells in patients with inflammatory diseases including rheumatoid arthritis and inflammatory bowel diseases, and is involved in inflammatory response when bound to fractalkine receptors (CX3CR1) expressed in immune cells. E6011 is an antibody therapy with a novel mechanism of action, and is believed to exhibit an anti-inflammatory effect by suppressing the migration and invasion of CX3CR1-positive immune cells.

Eisai is striving to accelerate the development of E6011 as a key product to contribute to improving the benefit for a greater number of patients and their families.

Media Inquiries:
Public Relations Department,
Eisai Co., Ltd.
+81-(0)3-3817-5120

1 Matsuoka K, et al., Safety, Tolerability and Efficacy of E6011, Anti-Human Fractalkine Monoclonal Antibody, in the First-Patient Study for Crohn’s Disease, Digestive Disease Week 2016, Poster Number Mo1890.
2 Tanaka Y, et al., Safety and Efficacy of E6011, an Anti-Fractalkine Monoclonal Antibody, in a First-in-Patient Phase 1/2 Study in Rheumatoid Arthritis. ACR 2015. Late-breaking Abstract Number 13L
3 Tanaka Y, et al., Safety, Pharmacokinetics and Efficacy of E6011, an Anti-Fractalkine Monoclonal Antibody, in a First-in-Patient Phase 1/2 Study in Japanese Patients with Rheumatoid Arthritis. 60th Annual General Assembly and Scientific Meeting of the Japan College of Rheumatology 2016. Poster Number ICW-C15-5.
4 Tanaka Y, et al., Safety and Efficacy of E6011, an Anti-Fractalkine Monoclonal Antibody, in a First-in-Patient Phase 1/2 Study in Rheumatoid Arthritis. EULAR Annual European Congress of Rheumatology 2016, Poster Number FRI0236
5 Data from the Japan Intractable Disease Information Center: http://www.nanbyou.or.jp/entry/81
6 World Health Organization, Chronic Rheumatic Conditions: http://www.who.int/chp/topics/rheumatic/en.

Tags: America
Previous Post

Sanofi Announces Positive Phase 3 Results For Investigational Titratable Fixed-Ratio

Next Post

Shire to license investigational gastric drug from Pfizer

Related Posts

WuXi Biologics and Virogen Bio partner to advance VG712
News

WuXi Biologics and Virogen Bio partner to advance VG712

19th June 2025
Construction of WuXi Biologics Microbial Manufacturing Site
News

Construction of WuXi Biologics Microbial Manufacturing Site

19th June 2025
Beyfortus From Sanofi to Make Imprint in 2025 26 RSV Season
News

Beyfortus From Sanofi to Make Imprint in 2025-26 RSV Season

19th June 2025
Thermo-Fischer-Accelerator Drug Development an Ideal Choice
News

Thermo Fischer Accelerator Drug Development an Ideal Choice

19th June 2025
IQVIA Custom Built AI Agents for Life Sciences Healthcare
News

IQVIA Custom-Built AI Agents for Life Sciences, Healthcare

19th June 2025
SCHOTT Pharma Invests
News

SCHOTT Pharma Invests EUR 100 Million in RTU Cartridges

9th June 2025
Next Post

Shire to license investigational gastric drug from Pfizer

Qucik Links

  • Drug Development
  • Manufacturing
  • News
  • Events & Conferences
  • Newsletter Archive
Pharma Advancement

About Us

Pharma Advancement is a leading Pharma information centric website. On one side Pharmaadvancement.com has established itself as one of the most efficient and comprehensive source of Pharma information online, dedicated to providing decision makers in all the Pharma industry sectors with reliable, accurate and useful insights into happenings in the Pharma sector.

Subscribe Us

System

  • Search
  • Sitemap
  • RSS Feed

Resources

  • Advertise with us
  • Contact Us
  • Download Mediapack
  • Newsletters Archive

© 2017 Copyright © Valuemediaservices 2017 All rights reserved.

No Result
View All Result
  • Home
  • Articles
  • Drug Development
  • Manufacturing
  • Supply Chain
  • Facilities
  • Insights
  • Events
  • Contact Us

© 2017 Copyright © Valuemediaservices 2017 All rights reserved.

Login to your account below

Forgotten Password?

Fill the forms bellow to register

All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In

Notifications